Harpagophytum procumbens ou "griffes du diable" - Analyse pharmacologique

Molécules chimiques et leurs actions pharmacologiques dans Harpagophytum procumbens (BURCH.) DC. EX MEISN. (Pedaliaceae) -- Devil's Claw, Grapple Plant

Les molécules chimiques naturelles contenues dans les plantes leur permettent de lutter contre les agressions du milieu dans lequel elles vivent : virus, bactéries, champignons. Nous sommes victimes des mêmes attaques ! C'est bien pourquoi, pour la santé, les plantes nous sont utiles. C'est également parce que nous possédons des récepteurs adéquats pour de telles molécules.

Harpagophytum, connu depuis la haute antiquité, présente une action favorable pour les douleursarticulaires. L'analyse chimique confirme la pratique.

ACETOSIDE Root:
Aldose-Reductase-Inhibitor IC50=0.4 ppm
BIOSIDE Root:
No activity reported.

CHLOROGENIC-ACID Root:
Aldose-Reductase-Inhibitor IC50=1.8 uM rat (strong activity); Allelochemic; Allergenic; Analgesic; Antiatherosclerotic; Antibacterial; Anticancer (Colon); Anticancer (Forestomach); Anticancer (Liver); Anticancer (Skin); Anticarcinogenic; Antidiabetic; AntiEBV; Antifeedant; Antigenotoxic; Antigonadotropic; Antihemolytic 10 uM; Antihepatotoxic; Antiherpetic; Antihistaminic; AntiHIV; Antihypercholesterolemic; Antihyperthyroid; Antiinflammatory; AntiLegionella; Antileukotriene; Antimelanogenic; Antimutagenic; Antinitrosaminic; Antioxidant IC50=54.2 uMIC53=200 ppm IC80=12 uM; Antiperoxidant IC50=36 uM; Antipolio; Antiradicular 10 uM 9 x quercetin; Antiseptic; Antisunburn; Antithyroid; Antitumor; Antitumor (Colon); Antitumor (Forestomach); Antitumor (Liver); Antitumor (Skin); Antitumor-Promoter IC25=10 uM; Antiulcer; Antiviral; Autotoxic; Cancer-Preventive; Cardioprotective; Chemopreventive; Cholagogue; Choleretic; Clastogenic; CNS-Active; CNS-Stimulant 1/6 Caffeine; Collagen-Sparing; Diuretic; Fungicide; Hepatoprotective; Histamine-Inhibitor; Hypoglycemic; Immunostimulant; Insectifuge; Interferonogenic; Juvabional; Larvistat; Leukotriene-Inhibitor; Lipoxygenase-Inhibitor IC23=5 mM; Metal-Chelator; NO-Genic; Ornithine-Decarboxylase-Inhibitor; Oviposition-Stimulant; Pesticide; Sunscreen; Sweetener; Vulnerary

CINNAMIC-ACID Root:
Aldose-Reductase-Inhibitor 4 ug/ml (weak activity); Allergenic; Anesthetic; Antibacterial; Antiinflammatory; Antimutagenic; Antispasmodic; Cancer-Preventive; Choleretic; Dermatitigenic; FLavor FEMA 4-40; Fungicide; Herbicide; Laxative; Lipoxygenase-Inhibitor; Pesticide; Tyrosinase-Inhibitor ID50=700 uM; Vermifuge

FISETIN Root:
5-Lipoxygenase-Inhibitor IC50 (uM)=11; ACE-Inhibitor IC50=150 uM/; Allergenic; Antihistaminic; Antimutagenic ID50=10-40 nM; Antioxidant; Antiviral; Cyclooxygenase-Inhibitor IC50 (uM) =80; Iodothyronine-Deiodinase-Inhibitor; Lipoxygenase-Inhibitor IC50 (uM)=11; Oxidase-Inhibitor; Pesticide; Topoisomerase-I-Inhibitor IC50=20.6 ug/ml; Topoisomerase-II-InhibitorIC50=8.2 ug/ml

HARPAGIDE Root:
(-)-Chronotropic; (-)-Inotropic; Analgesic; Antiarthritic; Antiinflammatory; Calcium-Antagonist
HARPAGOQUINONE Root:
No activity reported.
HARPAGOSIDE Root:
(+)-Inotropic; (-)-Chronotropic; Analgesic; Antiarrhythmic; Antiinflammatory IC50=10 uM; Calcium-Antagonist

ISOACETOSIDE Root:

No activity reported.

KAEMPFEROL Root:
11B-HSD-Inhibitor; 5-Lipoxygenase-Inhibitor IC50 (uM)=20; Aldose-Reductase-Inhibitor 100 uM; Antiaflatoxin IC50=3.28 ppm IC50=8.73 uM; Antiaggregant 30 uM; Antiallergic; Antibacterial 20 ug/ml; Anticancer; Antifertility 250 mg/kg/day/60 days/orl rat; Antigingivitic 20 ug/ml; Antiherpetic 23-92 ug/ml; Antihistaminic; Antiimplantation; Antiinflammatory 20 mg/kg200 mg/kg ipr rat; Antileukemic IC50=3.1 ug/ml; Antilymphocytic; Antimutagenic ID50=10-40 nM; Antioxidant 3/4 quercetin IC50=1.2 ug/ml IC50=40 uM; Antiperiodontic 20 ug/ml; Antiplaque; Antiradicular 7 x quercetin; Antiseptic 20 ug/ml; Antiserotonin 200 mg/kg ipr rat; Antispasmodic; Antistaphylococcic; Antitumor; Antitumor-Promoter; Antiulcer 50-200 mg/kg ipr rat; Antiviral 23-92 ug/ml; Apoptotic 60 uM; Aromatase-Inhibitor IC12=1 uM/l; cAMP-Phosphodiesterase-Inhibitor; Cancer-Preventive; Carcinogenic; Choleretic; Copper-Chelator; COX-2-Inhibitor; Cyclooxygenase-Inhibitor IC50 (uM) =20; Cytotoxic; Diaphoretic?; Diuretic; Estrogenic EC50=0.1-25 uM/l EC50=0.56 uM; Fungicide 20 ug/ml; Hepatoprotective IC50=1.30 ppmIC50=5.46 uM; HIV-RT-Inhibitor IC50=50-150 ug/ml; Hypotensive; ICAM-1-Inhibitor; iNOS-Inhibitor IC50=13.9 uM IC50=<15 uM; Inotropic; Iodothyronine-Deiodinase-Inhibitor; JNK-Inhibitor; Lipoxygenase-Inhibitor; MAO-Inhibitor; Mutagenic; Natriuretic; Neuroprotective; NO-Inhibitor IC50=13.9 uM; PAF-Inhibitor; Pesticide; Protisticide; Quinone-Reductase-Inducer 3 uM; Teratologic; TNF-alpha-Inhibitor IC50=3.99 uM; Topoisomerase-I-Inhibitor; Topoisomerase-II-Inhibitor IC50=8.1 ug/ml; Tyrosinase-Inhibitor ID50=230 uM; Uterotrophic EC50=0.1-25 uM/l; Vasodilator

LUTEOLIN Root:
Aldose-Reductase-Inhibitor EC=3 ppm IC50=0.45 uM rat; Antiallergic; Antiangiogenic IC60-75=10 uM; Antiatherogenic; Antibacterial MIC=500 ug/ml; Anticarcinogenic; Anticarcinomic; Anticataract EC=3 ppm; Anticomplementary; Antidermatic; Antiestrogenic; Antifeedant IC52=<1,000 ppm diet; Antiherpetic 11-23 ug/ml; Antihistaminic <10-15 uM; AntiHIV; Antiinflammatory =indomethacin; Antileukemic 20-50 uM; Antilymphomic; Antimelanomic; Antimutagenic ID50=0.44 ug/ml ID50=2-5 nM; Antinociceptive; Antioxidant IC50=10 uM; Antipolio; Antiproliferant; Antispasmodic; Antitumor 1-50 uM; Antitumor (brain); Antitumor (Colon); Antitumor (Kidney); Antitumor (Lung); Antitumor (Ovary); Antitumor (Pancreas); Antitumor (Skin) 20 uM; Antitumor (Stomach); Antitumor (Thyroid) 12-50 uM; Antitussive; Antiviral 11-23 ug/ml; Aphidifuge; Apoptotic 12-50 uM; Aromatase-Inhibitor IC35=1 uM/l; Beta-Glucuronidase-Inhibitor IC50=~40 uM; Calcium-Antagonist IC50=1.2 uM rbt; Cancer-Preventive; Chemopreventive; Choleretic; Cytotoxic 1-50 uM; Deiodinase-Inhibitor; DifferentiatorIC>40=40 uM; Diuretic; Estrogenic 58% genistein; Hepatoprotective; Hyaluronidase-Inhibitor IC50+=100-250 uM; Hypocholesterolemic; ICAM-1-Inhibitor; IKK-Inhibitor; iNOS-Inhibitor; Iodothyronine-Deiodinase-Inhibitor; Lipoxygenase-Inhibitor; MAPK-Inhibitor; Metalloproteinase-Inhibitor; MMP-9-Inhibitor 20 uM; Myorelaxant; NEP-Inhibitor IC50=>42 uM; NF-kB-Inhibitor; NO-Inhibitor; Pesticide; Proliferant; Prostaglandin-Synthetase-Inhibitor; Protein-Kinase-C-Inhibitor IC70=50 uM; PTK-Inhibitor 10-100 uM; Succinoxidase-Inhibitor; TNF-alpha-Inhibitor IC50=14.44 uM; Topoisomerase-I-Inhibitor; Vasodilator; VEGF-Inhibitor IC50=2-7 uM; Xanthine-Oxidase-Inhibitor IC50=0.11 ug/ml

OLEANOLIC-ACID Root:
Abortifacient; Antiallergic; Antiarrhythmic 40 mg/kg; Antiatherosclerotic; Antibacterial MIC=625-1,250 ug/ml; Anticarcinomic; Anticariogenic; Anticomplement IC40-50 0.01 mM/l gpg IC80-90 0.05 mM/l gpg; Antiedemic IC36=40 mg/kg ipr rat; Antifertility; Antigingivitic MIC=625-1,250 ug/ml; Antihepatotoxic; AntiHIV EC50=1.7 ug/ml IC50=21.8 ug/ml; Antihyperlipidemic; Antiinflammatory 40 mg/kg ipr; Antiischemic 40 mg/kg; Antileukemic; Antileukotriene IC50=17 uM; Antimalarial IC50=70-89 ug/ml; Antinephritic IC50=19-24 uM; Antioxidant IC46=10 uM; Antiperiodontic MIC=625-1,250 ug/ml; Antiperoxidant IC30=200 ug/ml; AntiPGE2 IC50=24 uM; Antiplaque MIC=625-1,250 ug/ml; Antiplasmodial IC50=70-89 ug/ml; Antisarcomic; Antiseptic MIC=625-1,250 ug/ml; AntiTGF-beta IC50=19-24 uM; Antitumor; Antitumor (Breast); Antitumor (Colon); Antitumor (Kidney); Antitumor (Lung); Antitumor (Pancreas); Antiulcer>carbenoxolone; Antiviral EC50=1.7 ug/ml IC50=21.8 ug/ml; Aromatase-Inhibitor; Beta-Blocker; Beta-Glucuronidase-Inhibitor ~100 mg/kg; Cancer-Preventive; Cardioprotective 40 mg/kg; Cardiotonic; COX-2-Inhibitor IC50=295 uM/; Cyclooxygenase-Inhibitor; Diuretic; Elastase-Inhibitor IC50=~15 uM; Hepatoprotective; Hypolipemic; Hypotensive; Immunomodulator; Leucocytogenic; NF-kB-Inhibitor; Phagocytotic; Piscicide; Prostaglandin-Synthesis-Inhibitor igs mus; Sedative; Uterotonic; Vasopressor

PROCUMBIDE Root:
No activity reported.

RAFFINOSE Root 3,000 ppm;
Flatugenic

STACHYOSE Root 6,000 - 8,000 ppm
Flatugenic